Menin.Org
Menin is a central player in the human cell that brings other proteins together to regulate the expression of genes that are key to cell growth, cell differentiation or cell senescence. Menin is a key scaffold protein that functionally crosstalks with various partners to regulate gene transcription and interplay with multiple signaling pathways. Menin is an important transcriptional regulator. It also impacts major processes such as cell cycle control, apoptosis and DNA damage repair. The MEN 1 gene and its associated protein, menin, was identified and named in 1997 by two research groups, the National Institute of Health group and the European MEN1 Consortium (Chandrasekharappa et al. 1997)